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If you have cirrhosis or creatinine clearance below 15 mL/min, alternative weight loss approaches may be safer pending more robust safety data in these populations

At present, there are certain limitations in evaluating the diagnostic and prognostic value of CRS using diagnostic/prognostic markers for heart failure or chronic kidney disease

If you go compounded anyway, take the FDAs red-flag list literally

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(5.2) Volume Depletion: Before initiating SYNJARDY or SYNJARDY XR, assess volume status and renal function in patients with impaired renal function, elderly patients, or patients on loop diuretics